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Lethal Ovarian Cancer Checked by Dual Attack on Immune Checkpoint, in Mice
April 13, 2022

Lethal Ovarian Cancer Checked by Dual Attack on Immune Checkpoint, in Mice

Hallmarks of a lethal form of ovarian cancer called “high-grade serous ovarian carcinoma” (HGSOC) are an immunosuppressive tumor microenvironment, insensitivity to checkpoint inhibitor immunotherapies, and elevated expression of checkpoint pathway ligands that thwart the immune system’s ability to kill tumor cells. Nearly 70% of HGSOC tumors express PTK2, a gene that encodes FAK (focal adhesion kinase), elevated levels of which signal poor survival outcomes.

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Engineered Bacteria May Protect Gut Microbiome from Harmful Effects of Antibiotics
April 13, 2022

Engineered Bacteria May Protect Gut Microbiome from Harmful Effects of Antibiotics

Antibiotics are life-saving drugs, but they can also harm the beneficial microbes that live in the human gut, and this can put some patients at risk of developing inflammation or opportunistic infections such as Clostridiodes difficile. As a potential strategy for reducing those risks, MIT engineers have developed a way to help protect the natural flora of the human digestive tract. The scientists took a strain of Lactococcus lactis bacteria that is safe for human consumption, and engineered it to produce an enzyme that breaks down a class of commonly used antibiotics called β-lactams..

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Physicists Engineer Ferroelectricity into Well-known Family of Semiconductors
April 11, 2022

Physicists Engineer Ferroelectricity into Well-known Family of Semiconductors

MIT physicists and colleagues have engineered a new property into a well-known family of semiconductors by manipulating ultrathin sheets of the materials only a few atomic layers thick. The MIT team showed that when two single sheets of a TMD, each only a few atomic layers thick, are stacked parallel to each other, the material becomes ferroelectric. In a ferroelectric material, positive and negative charges spontaneously head to different sides, or poles. Upon the application of an external electric field, those charges switch sides, reversing the polarization. In the new materials, all of this happens at room temperature.

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Good idea jeans: nanotechnology in textiles
April 11, 2022

Good idea jeans: nanotechnology in textiles

Self-cleaning gloves. An antibacterial shirt. Jeans that charge your phone, take your temperature, and report your electrolytes. A scarf that detects cancer. Does it sound like we’re living in the Jetsons yet? This could be our actual fabric future, according to researchers at the Joint School of Nanoscience and Nanoengineering “It is absolutely new,” says Dr. Tetyana Ignatova. “The combination of nanomaterials into textiles opens new avenues for the clothing industry. And we are very excited, because it is our societal responsibility, as scientists, to utilize our knowledge, expertise and technical skills for the sake of satisfying needs of society. This is why, at JSNN, we aim to convert the fundamental science into real applications to perform translational research.”.

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Young Researcher Wants to Change Materials Research Method
April 11, 2022

Young Researcher Wants to Change Materials Research Method

A new method will make the development of previously unknown materials for, e.g., solar cells both faster and more efficient. By closely combining experimental work with computer modelling, the young talented researcher Andrea Crovetto will create a new method for developing materials. The method is based on the need for a new material—for example a light absorber for a solar cell—and then determining which material will have the desired properties. This is in contrast with finding a new material and then researching what it can be used for.

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